This study was performed to investigate the changes of nerve after the injection of alcohol and glycerol at the infraorbital nerve in rats.
Using the eighteen Sprague-Dawley rats, weighing 200-2508, 99% alcohol, pure glycerol, and sterile saline was injected to the epineurium of the infraorbital nerve. Glycerol injected rats were devided into 0.01 ml, 0.03ml and 0.05m1 groups. The alcohol and control group were injected 0.03ml at the left infraorbital nerve. The following results were obtained by histopathological examination after 1 week, 1 month, and 3 months.
A few inflammatory cell infiltration and :no signs of nerve degeneration were noted in control group. Total nerve degeneration was noted in the alcohol group and no regeneration was noted in 1 month, and partial regeneration was noted at 3 month. The nerve 4egeneration was noted at the periphery of nerve bundle in 0.01 ml glycerol injection group. Total degeneration was noted in the 0.03m1and 0.05m1 glycerol injection group. These results suggest that injection of alcohol and glycerol are effective to nerve blockage by nerve degeneration, and nerve degenera-*on by glycerol injections is propotional to dose and nerve regeneration by glycerol injection is inversely propotional to dose.
|